Xs: 2.692893 Ys: 2.5538213 Publish year: 2003 keyword: complex_carbohydrates_diet source: Global title: Addition of inulin to a high carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentration in humans abstract: A high-carbohydrate, low-fat diet is recommended for the prevention of atherosclerosis, because it reduces plasma cholesterol concentrations. However, such a diet can increase plasma triacylglycerol concentrations--an undesirable side effect. The addition of nondigestible carbohydrate could reduce the risk of elevated triacylglycerol concentrations.
The objective was to determine whether the addition of a moderate dose of inulin to a moderately high-carbohydrate diet would decrease hepatic lipogenesis and plasma triacylglycerol concentrations and have a cholesterol-lowering action.
Eight healthy subjects were studied twice in a double-blind, randomized, placebo-controlled crossover study after consuming for 3 wk a moderately high-carbohydrate, low-fat diet (55% of total energy) plus an oral placebo or 10 g high-performance inulin/d. Hepatic lipogenesis and cholesterol synthesis (deuterated water method), plasma lipid concentrations, fatty acid synthase, acetyl-CoA carboxylase 1, and sterol responsive element binding protein 1c messenger RNA concentrations were measured in adipose tissue at the end of the 2 diet periods.
Plasma triacylglycerol concentrations and hepatic lipogenesis were lower after inulin than after placebo ingestion (P < 0.05), but cholesterol synthesis and plasma cholesterol concentrations were not significantly different between the 2 groups. None of the adipose tissue messenger RNA concentrations changed significantly after inulin ingestion.
The addition of high-performance inulin to a moderately high-carbohydrate, low-fat diet has a beneficial effect on plasma lipids by decreasing hepatic lipogenesis and plasma triacylglycerol concentrations. These results support the use of nondigestible carbohydrate for reducing risk factors for atherosclerosis.


Xs: 2.267707 Ys: 3.4125366 Publish year: 2018 keyword: complex_carbohydrates_diet source: Global title: Update on Dietary Management of Childhood Functional Abdominal Pain Disorders abstract: Diet plays a significant role for children with functional abdominal pain disorders. A large majority of these children identify at least 1 food that exacerbates their symptoms. Malabsorbed carbohydrates may have both direct and microbiome-mediated physiologic effects. There are several factors associated with carbohydrate symptom generation, including (1) the amount ingested, (2) ingestion with a meal, (3) small intestinal enzymatic activity, (4) consuming the carbohydrate with microorganisms capable of breaking down the carbohydrate, (5) the gut microbiome, and (6) host factors. Therapies include carbohydrate (single and/or comprehensive) restriction, selective prebiotic and/or enzyme supplementation. Fiber supplementation may also be beneficial.


Xs: 2.4300864 Ys: 1.9062986 Publish year: 2015 keyword: complex_carbohydrates_diet source: Global title: Indicators for the evaluation of diet quality abstract: The role of diet quality and physical activity in reducing the progression of chronic disease is becoming increasingly important. Dietary Quality Indices or Indicators (DQIs) are algorithms aiming to evaluate the overall diet and categorize individuals according to the extent to which their eating behaviour is "healthy". Predefined indexes assess dietary patterns based on current nutrition knowledge and they have been developed primarily for nutritional epidemiology to assess dietary risk factors for non-communicable diseases. There are many different types of DQIs. There are three major categories of DQIs: a) nutrient-based indicators; b) food/food group based indicators; and c) combination indexes, the vast majority of DQIs, which often include a measure of diet variety within and across food groups, a measure of adequacy i.e. nutrients (compared to requirements) or food groups (quantities or servings), a measure of nutrients/foods to consume in moderation, and an overall balance of macronutrients. The Healthy Eating Index (HEI), the Diet Quality Index (DQI), the Healthy Diet Indicator (HDI) and the Mediterranean Diet Score (MDS) are the four 'original' diet quality scores that have been referred to and validated most extensively. Several indexes have been adapted and modified from those originals. In particular, many variations on the MDS have been proposed, included different alternate MDS and Mediterranean Diet Adherence Screener (MEDAS). Primary data source of DQI's are individual dietary data collection tools, namely 24 h quantitative intake recalls, dietary records and food frequency questionnaires. Nutrients found in many scores are total fat, saturated fatty acids or the ratio of monounsaturated fatty acids to saturated fatty acids or the latter SFA to polyunsaturated fatty acids. Cholesterol, protein content and quality, complex carbohydrates, mono- and disaccharides, dietary fibre and sodium are also found in various scores. All DQIs, except those that only contain nutrients, include the components fruits and vegetables; additional attributes are legumes or pulses, nuts and seeds. Meat and meat products, namely red and processed meat, poultry, and milk and dairy products are also included in many scores. Other foods contained in some DQIs e.g. MDS are olive oil and fish. Nowadays, there is interest in defining more than DQIs, healthy life indices (HLIs), which give information on behaviours associated with specific patterns and beyond dietary habits they include physical activity, rest and selected socio-cultural habits. The Mediterranean Lifestyle (MEDLIFE) index has been recently created based on the current Spanish Mediterranean food guide pyramid and it includes both the assessment of food consumption directly related to the Mediterranean diet, physical activity and rest and other relevant cultural information. However, a global HLI should consider, based on the Iberoamerican Nutrition Foundation (FINUT) Pyramid of Healthy Lifestyles, in addition to food groups and nutrients, selected items on food safety e.g. consumption rate of proceed foods, food handling, preparation and storage and access to drinking water, selected food habits, including alcoholic beverage and salt consumption patterns, purchase of seasonal and local foods, home cooking and conviviality, as well as patterns of physical activity, sedentary and rest habits and some selected sociocultural habits, particularly those related to food selection, religious beliefs and socializing with friends.
Copyright AULA MEDICA EDICIONES 2015. Published by AULA MEDICA. All rights reserved.


Xs: 2.212196 Ys: 3.2837949 Publish year: 2001 keyword: complex_carbohydrates_diet source: Global title: Effect of two fermentable carbohydrates (inulin and resistant starch) and their combination on calcium and magnesium balance in rats abstract: Resistant starch and inulin are complex carbohydrates that are fermented by the microflora and known to increase colonic absorption of minerals in animals. The fermentation of these substrates in the large bowel to short-chain fatty acids is the main reason for this increase in mineral absorption. The purpose of the present study was to examine the potential synergistic effect of a combination of these two fermentable carbohydrates. For this purpose, thirty-two adult male Wistar rats weighing 200 g were used in the present study. The rats were distributed into four groups, and fed for 21 d a fibre-free basal purified diet or diet containing 100 g inulin, or 150 g resistant starch (raw potato starch)/kg diet or a blend of 50 g inulin and 75 g resistant starch/kg diet. After an adaptation period of 14 d, the rats were then transferred to metabolic cages and dietary intake, faeces and urine were monitored for 5 d. The animals were then anaesthetized and caecal Ca and Mg absorption were measured. Finally, the rats were killed and blood, caecum and tissues were sampled. Ca and Mg levels were assessed in diets, faeces, urine, caecum and plasma by atomic absorption spectrometry. Our results confirmed that inulin and resistant starch ingestion led to considerable caecal fermentation in the three experimental groups compared with the control group diet. Moreover, both carbohydrates significantly increased the intestinal absorption and balance of Ca and Mg, without altering the plasma level of these two minerals. Interestingly, the combination of the studied carbohydrates increased significantly the caecal soluble Ca and Mg concentrations, the apparent intestinal absorption and balance of Ca, and non-significantly the plasma Mg level. In conclusion, a combination of different carbohydrates showed synergistic effects on intestinal Ca absorption and balance in rats. Further studies with other types of carbohydrate combinations should be carried out to extend these findings.


Xs: 2.0646093 Ys: 2.4487784 Publish year: 2017 keyword: complex_carbohydrates_diet source: Global title: The Role of Carbohydrates in Metabolic Syndrome abstract: The metabolic syndrome (MetS) was defined as a condition characterized by disturbed glucose and insulin metabolism, central obesity, mild dyslipidemia, and hy-pertension. These conditions are important risk factors for diabetes, cardiovascular disease, and other chronic diseases. It etiology is a complex interaction between genetic , metabolic, and dietetic factors. To overcome the epidemic values of obesity and MetS currently registered, nutritional interventions are needed and the substitution of diet components may be a good strategy. Usually, metabolic disorders that are present in MetS are associated to high consumption of fat; however, as well as fat, carbohydrates have an important influence in MetS components. Taking into account that carbohydrates may be converted to glucose or fermented, producing fatty acids or short-chain fatty acids respectively, is essential consider its influence in lipids bioavailability for the human metabolism. The impact of carbohydrates consumption on human metabolism continues to be a controversial topic and several metabolic characteristics should be considered. Thus, this chapter focuses on the role of carbohydrates in the MetS and associated complication.


Xs: 3.0123744 Ys: 3.685798 Publish year: 2016 keyword: complex_carbohydrates_diet source: Global title: Gut complex carbohydrates and intestinal microflora in broiler chickens fed with oregano (Origanum vulgare L.) aqueous extract and vitamin E abstract: One hundred and seventy one-day-old female broiler chicks were randomly divided into three groups fed with different dietary treatments: basal control diet (C); C supplemented (2 g/kg) with an oregano aqueous extract (O); C supplemented (150 mg/kg) with vitamin E (E). Growth performance was evaluated at 21 (T1) and 42 days (T2). On the same days, morphological, histochemical and microbiological analyses were performed. The O group showed the highest (p < 0.01) body weight at T1, while no differences were observed at T2. Light microscopic observation and conventional histochemistry showed no differences with regard to the two sampling times, whereas significant differences emerged among the treatments. The O treatment generally enhanced goblet cell reactivity more than both the C and E treatments. Coliform count was lower in the ileum tract of the O group at both T1 and T2 (p < 0.05) and increased with age in all groups. Escherichia coli showed the lowest values in the caecum of the O group (p < 0.001) at both sampling times. Enterococci, lactobacilli and staphylococci populations showed no differences among the different experimental groups in the caecum. In the ileum, the O group did not exhibit the sharp decline (p < 0.001) in the lactic acid bacteria population observed in the other two experimental groups. In conclusion, oregano aqueous extract supplementation seemed to elicit the best response among treatments, enabling better growth performance, enhancing both the quantity and quality of glycoconjugates involved in indirect defence actions and significantly reducing both the coliform and E. coli counts.


Xs: 3.8292522 Ys: 3.8330097 Publish year: 2002 keyword: complex_carbohydrates_diet source: Global title: Carbohydrates in fish nutrition: Effects on growth, glucose metabolism and hepatic enzymes abstract: The utilisation of dietary carbohydrates and their effects on fish metabolism are reviewed. Details on how dietary carbohydrates affect growth, feed utilisation and deposition of nutrients are discussed. Variations in plasma glucose concentrations emphasizing results from glucose tolerance tests, and the impact of adaptation diets are interpreted in the context of secondary carbohydrate metabolism. Our focus then shifts to selected aspects of hormonal regulation of carbohydrate metabolism and dietary carbohydrates and their variable effects on glycogen and glucose turnover. We analyse the interaction of carbohydrates with other nutrients, especially protein and protein sparing, and de novo synthesis of lipids, and finish by discussing the correlation of dietary carbohydrates with fish health.


Xs: 1.5928106 Ys: 2.347617 Publish year: 2020 keyword: complex_carbohydrates_diet source: Global title: The Role of Dietary Carbohydrates in Gestational Diabetes abstract: Gestational diabetes (GDM) is hyperglycemia that is recognized for the first time during pregnancy. GDM is associated with a wide range of short- and long-term adverse health consequences for both mother and offspring. It is a complex disease with a multifactorial etiology, with disturbances in glucose, lipid, inflammation and gut microbiota. Consequently, its management is complex, requiring patients to self-manage their diet, lifestyle and self-care behaviors in combination with use of insulin. In addition to nutritional recommendations for all pregnant women, special attention to dietary carbohydrate (CHO) amount and type on glucose levels is especially important in GDM. Dietary CHO are diverse, ranging from simple sugars to longer-chain oligo- and poly- saccharides which have diverse effects on blood glucose, microbial fermentation and bowel function. Studies have established that dietary CHO amount and type can impact maternal glucose and nutritional recommendations advise women with GDM to limit total intake or choose complex and low glycemic CHO. However, robust maternal and infant benefits are not consistently shown. Novel approaches which help women with GDM adhere to dietary recommendations such as diabetes-specific meal replacements (which provide a defined and complete nutritional composition with slowly-digested CHO) and continuous glucose monitors (which provide unlimited monitoring of maternal glycemic fluctuations) have shown benefits on both maternal and neonatal outcomes. Continued research is needed to understand and develop tools to facilitate patient adherence to treatment goals, individualize interventions and improve outcomes.


Xs: 2.5620549 Ys: 2.126238 Publish year: 2019 keyword: complex_carbohydrates_diet source: Global title: Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) abstract: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. Obesity, low-grade chronic inflammatory status, and insulin-resistance (IR) often coexist in PCOS. The Mediterranean diet (MD) is an anti-inflammatory dietary pattern, which is rich in complex carbohydrates and fiber, and high in monounsaturated fat. There is a close association among obesity, low-grade chronic inflammation, IR, and hormonal derangements in PCOS. The main aim of the present study was to evaluate the adherence to MD, the dietary intake, and the body composition and their association with PCOS clinical severity in a cohort of treatment-naïve women with PCOS when compared with a control group of healthy women matched for age and body mass index (BMI). In this case-controlled, cross-sectional study, we enrolled 112 patients with PCOS and 112 controls. PREvención con DIetaMEDiterránea (PREDIMED) and seven-day food records were used to evaluate the degree of adherence to the MD and dietary pattern, respectively. Body composition was evaluated by bioelectrical impedance analysis (BIA) phase-sensitive system. Testosterone levels and Ferriman-Gallwey score assessed the clinical severity of PCOS. C-reactive protein (CRP) levels were determined with a nephelometric assay with CardioPhase high sensitivity. PCOS women showed higher testosterone levels, Ferriman-Gallwey score, fasting insulin and glucose levels, and Homeostatic Model Assessment (HoMA)-IR when compared with the control group (p < 0.001). In addition, we found that the PCOS women consumed less extra-virgin olive oil, legumes, fish/seafood, and nuts compared with control group. Despite no differences in energy intake between the two groups, the PCOS women consumed a lower quantity of complex carbohydrate, fiber, monounsaturated fatty acids (MUFA), and n-3 polyunsaturated fatty acid (PUFA), and higher quantity of simple carbohydrate, total fat, saturated fatty acid (SFA), PUFA and n-6 PUFA than the control group. The PCOS women have an adverse body composition when compared with controls, with the lowest values of phase angle (PhA) and fat-free mass (p < 0.001). Additionally, after adjusting for BMI and total energy intake, testosterone levels showed significant negative correlations with PREDIMED score (p < 0.001) and consumption of protein (p = 0.005), complex carbohydrate (p < 0.001), fiber (p < 0.001), MUFA (p < 0.001), n-3 PUFA (p = 0.001), and positive associations with CRP levels, simple carbohydrate, SFA, n-6 PUFA (p < 0.001, respectively), and PUFA (p = 0.002). The cutoff for PREDIMED score ≤ 6 (p < 0.001, area under the curve (AUC) 0.848, standard error 0.036, 95% confidence interval (CI) 0.768 to 0.909) could serve as a threshold for significantly increased risk of high value of testosterone Nutrients 2019, 11, 2278 2 of 21 levels. In conclusion, a novel direct association between the adherence to MD and the clinical severity of the disease was reported in women with PCOS. This association could support a therapeutic role of foods and nutrients of the Mediterranean dietary pattern in the PCOS pathogenesis likely involving their inflammatory status, IR, and hyperandrogenemia. In addition, we reported a different body composition that is characterized by lower PhA and fat-free mass than controls. These data suggested a role of PhA as a useful marker of the clinical severity of this syndrome and provided strong evidence regarding the strategic relevance of the nutritional assessment in the management of women with PCOS.


Xs: 2.4388046 Ys: 4.187518 Publish year: 2022 keyword: complex_carbohydrates_diet source: Global title: Phenotypic and Genomic Diversification in Complex Carbohydrate-Degrading Human Gut Bacteria abstract: Symbiotic bacteria are responsible for the majority of complex carbohydrate digestion in the human colon. Since the identities and amounts of dietary polysaccharides directly impact the gut microbiota, determining which microorganisms consume specific nutrients is central for defining the relationship between diet and gut microbial ecology. Using a custom phenotyping array, we determined carbohydrate utilization profiles for 354 members of the Bacteroidetes, a dominant saccharolytic phylum. There was wide variation in the numbers and types of substrates degraded by individual bacteria, but phenotype-based clustering grouped members of the same species indicating that each species performs characteristic roles. The ability to utilize dietary polysaccharides and endogenous mucin glycans was negatively correlated, suggesting exclusion between these niches. By analyzing related Bacteroides ovatus/Bacteroides xylanisolvens strains that vary in their ability to utilize mucin glycans, we addressed whether gene clusters that confer this complex, multilocus trait are being gained or lost in individual strains. Pangenome reconstruction of these strains revealed a remarkably mosaic architecture in which genes involved in polysaccharide metabolism are highly variable and bioinformatics data provide evidence of interspecies gene transfer that might explain this genomic heterogeneity. Global transcriptomic analyses suggest that the ability to utilize mucin has been lost in some lineages of B. ovatus and B. xylanisolvens, which harbor residual gene clusters that are involved in mucin utilization by strains that still actively express this phenotype. Our data provide insight into the breadth and complexity of carbohydrate metabolism in the microbiome and the underlying genomic events that shape these behaviors.


Xs: 1.9621189 Ys: 2.0834584 Publish year: 2000 keyword: complex_carbohydrates_diet source: Global title: The role of dietary fat in body fatness: Evidence from a preliminary meta-analysis of ad libitum low-fat dietary intervention studies abstract: The role of high-fat diets in weight gain and obesity has been questioned because of inconsistent reports in the literature concerning the efficacy of ad libitum low-fat diets to reduce body weight. We conducted a meta-analysis of weight loss occurring on ad libitum low-fat diets in intervention trials, and analysed the relationship between initial body weight and weight loss. We selected controlled trials lasting more than 2 months comparing ad libitum low-fat diets with a control group consuming their habitual diet or a medium-fat diet ad libitum published from 1966 to 1998. Data were included from 16 trials with a duration of 2-12 months, involving 1728 individuals. No trials on obese subjects fulfilled the inclusion criteria. The weighted difference in weight loss between intervention and control groups was 2.55 kg (95% CI, 1.5-3.5; P < 0.0001). Weight loss was positively and independently related to pre-treatment body weight (r = 0.52, P < 0.05) and to reduction in the percentage of energy as fat (0.37 kg/%, P < 0.005) in unweighted analysis. Extrapolated to a BMI of about 30 kg/m2 and assuming a 10% reduction in dietary fat, the predicted weight loss would be 4.4 kg (95% CI, 2.0 to -6.8 kg). Because weight loss was not the primary aim in 12 of the 16 studies, it is unlikely that voluntary energy restriction contributed to the weight loss. Although there is no evidence that a high intake of simple sugars contributes to passive overconsumption, carbohydrate foods with a low glycaemic index may be more satiating and exert more beneficial effects on insulin resistance and cardiovascular risk factors. Moreover, an increase in protein content up to 25% of total energy may also contribute to reducing total energy intake. In conclusion, a low-fat diet, high in protein and fibre-rich carbohydrates, mainly from different vegetables, fruits and whole grains, is highly satiating for fewer calories than fatty foods. This diet composition provides good sources of vitamins, minerals, trace elements and fibre, and may have the most beneficial effect on blood lipids and blood-pressure levels. A reduction in dietary fat without restriction of total energy intake prevents weight gain in subjects of normal weight and produces a weight loss in overweight subjects, which is highly relevant for public health.


Xs: 2.3861294 Ys: 1.6167605 Publish year: 2021 keyword: complex_carbohydrates_diet source: Global title: Low-Carbohydrate Diets in Korea: Why Does It Matter, and What Is Next? abstract: In recent years, low-carbohydrate diets have become highly popular in Korea as a means to lose weight. People following this regime believe that fat and protein can be consumed in unlimited quantities, as long as carbohydrate intake is strictly restricted. However, low-carbohydrate diets are more complex than simply reducing carbohydrate intake. Meta-analyses of randomized clinical trials revealed that low-carb diets are at least as effective as low-fat diets in terms of weight loss, but their cardiovascular effects vary. Low-carbohydrate diets confer more beneficial effects on weight loss and lipid profiles such as triglycerides and high-density lipoprotein cholesterol but exhibited detrimental effects on lipid profiles such as total and low-density lipoprotein. Korean diets are typically high in carbohydrates, where carbohydrate intake is in the range of 50%-80% of total energy. Within this range of carbohydrate intake, high carbohydrate intake was associated with an increased risk of elevated triglyceride and high-density lipoprotein-cholesterol levels but with a reduced risk of elevated total and low-density lipoprotein-cholesterol levels. The optimal range of carbohydrate intake was depicted by a U-shaped relationship between carbohydrate intake and mortality, with 50%-60% of energy from carbohydrates having the lowest mortality risk. The distribution of macronutrients varied greatly according to age and sex groups in Korea. There is no single diet that can be recommended to all individuals, especially if focusing only on the quantity of macronutrients as opposed to their quality. The health benefits of low-carbohydrate or low-fat diets may depend on the source of protein and fat and the carbohydrate quality.


Xs: 2.752572 Ys: 1.6285971 Publish year: 2008 keyword: complex_carbohydrates_diet source: Global title: Perilipin Polymorphism Interacts with Dietary Carbohydrates to Modulate Anthropometric Traits in Hispanics of Caribbean Origin abstract: Perilipin (PLIN) is the major protein surrounding lipid droplets in adipocytes and regulates adipocyte metabolism by modulating the interaction between lipases and triacylglycerol stores. Associations between PLIN gene polymorphisms and obesity risk have been described, but interactions with dietary macronutrients require further attention. We examined whether dietary macronutrients (e.g. carbohydrates and fats) modulated the associations of the common PLIN 11482G > A (rs894160) single nucleotide polymorphism with obesity. We studied a population-based sample of Caribbean-origin Hispanics (n = 920, aged 45-74 y) living in the Boston area. Obesity measures (waist and hip circumference, BMI) did not differ between GG subjects and carriers of the A allele (GA and AA). In multivariate linear regression models, we found a significant interaction between complex carbohydrate intake as a continuous variable and PLIN 11482 G > A genotype for waist circumference (P = 0.002). By dichotomizing complex carbohydrate intake, we found significantly different effects across PLIN 11482G > A genotypes. When complex carbohydrate intake was <144 g/d, waist circumference was larger in PLIN 11482G > A carriers (P = 0.024). Conversely, when complex carbohydrate intake was >/=144 g/d, waist and hip circumferences were less in PLIN 11482G > A carriers (P < 0.05). These interactions were not found for simple sugars or total carbohydrates. We identified a significant gene-diet interaction associated with obesity at the PLIN locus. In subjects with higher complex carbohydrate intake, the minor allele was protective against obesity, whereas in subjects with lower carbohydrate intake, the minor allele was associated with increased obesity. These interactions may be relevant to dietary management of obesity.


Xs: 2.6192453 Ys: 2.6176178 Publish year: 2006 keyword: complex_carbohydrates_diet source: Global title: Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome abstract: Previously, we have demonstrated that chronic consumption of a high-fat, high-refined sugar (HFS) diet results in metabolic syndrome which is marked by obesity, insulin resistance, hyperlipidemia, and hypertension in Fischer rats. Metabolic syndrome in this model is associated with oxidative stress, avid nitric oxide (NO) inactivation by reactive oxygen species (ROS), diminished NO bioavailability, and dysregulation of NO synthase isotypes. Although occurrence of oxidative stress and its impact on NO metabolism are well established, the molecular source(s) of ROS in this model is unknown. In an attempt to explore this issue, we measured protein expressions of the key ROS-producing enzyme, NAD(P)H oxidase, and the main antioxidant enzymes, superoxide dismutase (CuZn SOD and Mn SOD), catalase, glutathione peroxidase (GPX), and heme oxygenase-2 (HO-2), in the kidney and aorta of Fischer rats fed an HFS or low-fat, complex-carbohydrate diet for 7 months. In addition, plasma lipid peroxidation product (malondialdehyde) as well as endothelium-dependent and -independent vasorelaxation (aorta rings) was determined. The results showed a significant upregulation of gp91(phox) subunit of NAD(P)H oxidase and downregulations of SOD isoforms, GPX, and HO-2 in the kidney and aorta of the HFS-fed animals. This was associated with increased plasma malondialdehyde concentration and impaired vasodilatory response to acetylcholine, but not the NO donor, Na nitroprusside. The latter findings confirm the presence of oxidative stress and endothelial dysfunction in the HFS-fed rats. Oxidative stress and endothelial dysfunction in the diet-induced metabolic syndrome are accompanied by upregulation of NAD(P)H oxidase, pointing to increased ROS production capacity, and downregulation of SOD isoforms, GPX, and HO-2, the key enzymes in the antioxidant defense system.


Xs: 2.4479733 Ys: 3.8137822 Publish year: 2016 keyword: complex_carbohydrates_diet source: Global title: Diet, microorganisms and their metabolites, and colon cancer abstract: Colorectal cancer is one of the so-called westernized diseases and the second leading cause of cancer death worldwide. On the basis of global epidemiological and scientific studies, evidence suggests that the risk of colorectal cancer is increased by processed and unprocessed meat consumption but suppressed by fibre, and that food composition affects colonic health and cancer risk via its effects on colonic microbial metabolism. The gut microbiota can ferment complex dietary residues that are resistant to digestion by enteric enzymes. This process provides energy for the microbiota but culminates in the release of short-chain fatty acids including butyrate, which are utilized for the metabolic needs of the colon and the body. Butyrate has a remarkable array of colonic health-promoting and antineoplastic properties: it is the preferred energy source for colonocytes, it maintains mucosal integrity and it suppresses inflammation and carcinogenesis through effects on immunity, gene expression and epigenetic modulation. Protein residues and fat-stimulated bile acids are also metabolized by the microbiota to inflammatory and/or carcinogenic metabolites, which increase the risk of neoplastic progression. This Review will discuss the mechanisms behind these microbial metabolite effects, which could be modified by diet to achieve the objective of preventing colorectal cancer in Western societies.


Xs: 3.777169 Ys: 3.7827473 Publish year: 2014 keyword: complex_carbohydrates_diet source: Global title: Comparative studies on endocrine status and gene expression of hepatic carbohydrate metabolic enzymes in juvenile GIFT tilapia (Oreochromis niloticus) fed high-carbohydrate diets abstract: The effects of high-carbohydrate diets on endocrine status and gene expression of hepatic metabolism enzymes in genetically improved farmed tilapia (GIFT) juveniles (Oreochromis niloticus) at different sampling times were investigated. Two isonitrogenous (28% crude protein) and isolipidic (5% crude lipid) diets were formulated to contain 40% gelatinized wheat starch (WS) or glucose (GLU). Diets were assigned to triplicate groups of 30 fish (initial weight: 51 g) for 42 days. At the end of the trial, there were no significant difference in growth between WS group and GLU group. Hepatosomatic and visceral index and liver glycogen in juveniles were not significantly influenced by high-carbohydrate diets on Day 42 (P > 0.05). Plasma glucose was higher in the GLU group than the WS group from Day 7 onwards. Data on gene expression showed that G6PD, but not GK and G6Pase, were affected by high-carbohydrate diet. The levels of G6PD in the GLU group on Days 35 and 42 were significantly higher than those in the WS group. Serum IGF-I levels of both groups significantly decreased on Day 42, whereas serum insulin levels were unaltered by high-carbohydrate diet. The serum GH level decreased significantly in the GLU group compared with the WS group. Overall, our data suggest that high-glucose diets were efficiently used as an energy source by GIFT tilapia juveniles, and significantly affected liver lipogenic activity and serum GH levels.


Xs: 1.9162627 Ys: 2.1320672 Publish year: 2003 keyword: complex_carbohydrates_diet source: Global title: Low-carbohydrate diets: What are the long-term health implications? abstract: Low-carbohydrate diets for weight loss are receiving a lot of attention of late. Reasons for this interest include a plethora of low-carbohydrate diet books, the over-sensationalism of these diets in the media and by celebrities, and the promotion of these diets in fitness centres and health clubs. The re-emergence of low-carbohydrate diets into the spotlight has lead many people in the general public to question whether carbohydrates are inherently 'bad' and should be limited in the diet. Although low-carbohydrate diets were popular in the 1970s they have resurged again yet little scientific fact into the true nature of how these diets work or, more importantly, any potential for serious long-term health risks in adopting this dieting practice appear to have reached the mainstream literature. Evidence abounds that low-carbohydrate diets present no significant advantage over more traditional energy-restricted, nutritionally balanced diets both in terms of weight loss and weight maintenance. Studies examining the efficacy of using low-carbohydrate diets for long-term weight loss are few in number, however few positive benefits exist to promote the adoption of carbohydrate restriction as a realistic, and more importantly, safe means of dieting. While short-term carbohydrate restriction over a period of a week can result in a significant loss of weight (albeit mostly from water and glycogen stores), of serious concern is what potential exists for the following of this type of eating plan for longer periods of months to years. Complications such as heart arrhythmias, cardiac contractile function impairment, sudden death, osteoporosis, kidney damage, increased cancer risk, impairment of physical activity and lipid abnormalities can all be linked to long-term restriction of carbohydrates in the diet. The need to further explore and communicate the untoward side-effects of low-carbohydrate diets should be an important public health message from nutrition professionals.


Xs: 2.7362309 Ys: 2.0765874 Publish year: 2004 keyword: complex_carbohydrates_diet source: Global title: Dietary Fat and Risk of Coronary Heart Disease: Possible Effect Modification by Gender and Age abstract: In a 16-year follow-up study (ending in 1998) of 3,686 Danish men and women aged 30-71 years at recruitment, the association between energy intake from dietary fat and the risk of coronary heart disease was evaluated while assessing the possible modifying role of gender and age. In the models used, total energy and protein intake were fixed. Differences in intake of energy from fat thus reflected complementary differences in intake of energy from carbohydrates. A 5% higher level of energy from saturated fat intake was associated with a 36% greater risk of coronary heart disease among women (hazard ratio (HR) = 1.36, 95% confidence interval (CI): 0.98, 1.88). No overall association between saturated fat and coronary heart disease was found among men. However, age-dependent analyses showed that saturated fat was positively associated with coronary heart disease among the younger men (HR = 1.29, 95% CI: 0.87, 1.91) and the younger women (HR = 2.68, 95% CI: 1.40, 5.12) but not among the older men (HR = 0.94, 95% CI: 0.70, 1.28) and the older women (HR = 1.22, 95% CI: 0.86, 1.71). Polyunsaturated fat was inversely associated with coronary heart disease among women and men, although not significantly. In conclusion, the present study suggests that coronary heart disease risk relates to both the quantity and the quality of dietary fats.


Xs: 1.7071078 Ys: 2.3540647 Publish year: 2003 keyword: complex_carbohydrates_diet source: Global title: High-carbohydrate versus high-fat diets in endurance sports abstract: Summary High-carbohydrate diets have been commonplace in the athletic population for many years but more recently high-fat diets have gained popularity. It is becoming more and more clear that in trained athletes extreme dietary and training regimes are not ne- cessary to achieve optimal muscle glycogen stores. With adequate carbohydrate intake (7-10 g·kg -1 body mass per day) muscle glycogen stores can be returned to normal resting levels (to 350- 800 mmol·kg -1 dry weight muscle) within 24 hours. Normalized stores appear adequate for the fuel needs of events of less than 90 minutes in duration and supercompensated glycogen levels do not seem to enhance the performance of these events. Optimal gly- cogen stores will typically postpone fatigue and extend the dura- tion of steady state exercise by ~20%, and improve performance over a set distance or workload by 2-3%. Extremely high-carbo- hydrate intakes are not necessary to achieve this and may result in increased risk factors for cardiovascular diseases. High-fat diets can result in increased fat oxidation after 5 days on a high-fat diet which is only partly explained by substrate availab- ility. Adaptations at the muscular level that result in changes in substrate utilization in response to a diet may also occur after 5 days. However, high-fat diets will reduce muscle and liver gly- cogen concentrations and therefore performance may be reduced. The potential benefits of an adaptation period to a high-fat diet followed by a period of carbo-loading are not clear but the vast majority of studies reports no effect on performance. Therefore, there is currently very little or no evidence to support the use of high-fat diets and long term health effects of such diets in athletes are unknown. A diet containing 7-10 g·kg -1 body mass per day of carbohydrate, 10-15 energy percent from protein and the remain- der from fat seems a good compromise that will allow endurance athletes to train hard and perform well.


Xs: 2.266053 Ys: 2.4741602 Publish year: 2000 keyword: complex_carbohydrates_diet source: Global title: Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects abstract: We previously reported that a eucaloric, low fat, liquid formula diet enriched in simple carbohydrate markedly increased the synthesis of fatty acids in lean volunteers. To examine the diet sensitivity of obese subjects, 7 obese and 12 lean volunteers were given two eucaloric low fat solid food diets enriched in simple sugars for 2 weeks each in a random-order, cross-over design (10% fat, 75% carbohydrate vs. 30% fat, 55% carbohydrate, ratio of sugar to starch 60:40). The fatty acid compositions of both diets were matched to the composition of each subject's adipose tissue and fatty acid synthesis measured by the method of linoleate dilution in plasma VLDL triglyceride. In all subjects, the maximum % de novo synthesized fatty acids in VLDL triglyceride 3;-9 h after the last meal was higher on the 10% versus the 30% fat diet. There was no significant difference between the dietary effects on lean (43+/-13 vs. 12+/-13%) and obese (37+/-15 vs. 6+/-6%) subjects, despite 2-fold elevated levels of insulin and reduced glucagon levels in the obese. Similar results were obtained for de novo palmitate synthesis in VLDL triglyceride measured by mass isotopomer distribution analysis after infusion of [(13)C]acetate. On the 10% fat diet, plasma triglycerides (fasting and 24 h) were increased and correlated with fatty acid synthesis. Triglycerides were higher when fatty acid synthesis was constantly elevated rather than having diurnal variation.Thus, eucaloric, solid food diets which are very low in fat and high in simple sugars markedly stimulate fatty acid synthesis from carbohydrate, and plasma triglycerides increase in proportion to the amount of fatty acid synthesis. However, this dietary effect is not related to body mass index, insulin, or glucagon levels.


Xs: 2.404393 Ys: 2.8744614 Publish year: 2023 keyword: complex_carbohydrates_diet source: Global title: Does a gluten-free diet result in nutritional deficiencies? – a review of literature abstract: Introduction and purpose:

Gluten-free diet have gained immense popularity in recent years, both as a treatment for coeliac disease and as a lifestyle choice for those who believe it is healthier. However, concerns have been raised about potential nutrient inadequacies resulting from the elimination of gluten-containing grains. The purpose of this review is to assess the state of knowledge regarding the impact of a gluten-free diet on nutritional status.

Materials and methods:

A comprehensive search was conducted using electronic database PubMed to identify relevant studies published between 1999 and 2022. Keywords such as "gluten-free diet" and "nutritional deficiencies" were used in combination with Boolean operators to refine the search.

A brief description of the state of knowledge:

Analysis of studies revealed that individuals adhering to a gluten-free diet may be at risk of nutritional deficiencies including micronutrients such as vitamin D, vitamin E, vitamin B complex along with minerals, in particular iron, zinc, calcium, magnesium as well as fibre. Furthermore, higher levels of fat and sugar were observed in the composition of gluten-free products.

Conclusions:

Based on the current body of literature, it is evident that a gluten-free diet results in certain nutritional deficiencies. Individuals following gluten-free diet should be aware of potential risks and take appropriate measures to ensure a well-balanced and nutrient-rich diet. Nutritional guidance should be provided to individuals to address specific nutrient deficiencies associated with a gluten-free diet.


Xs: 2.2581944 Ys: 3.2318332 Publish year: 2019 keyword: complex_carbohydrates_diet source: Global title: Analytical Methods and Advances to Evaluate Dietary Fiber abstract: The determination of fiber is a complex issue in the field of analytical chemistry, and the term “dietary fiber” includes a wide variety of carbohydrates of diverse chemical nature. Moreover, the demonstration of the health benefits of these carbohydrates has been recently included in the definition of dietary fiber. Thus, it is necessary to develop effective protocols for the quantification of dietary fiber and for the elucidation of the chemical structure of these molecules due to the strong structure-function relationships appreciated in carbohydrates. As the field of analytical chemistry evolves, new methods and technologies are being developed to study dietary fiber. The use of these new techniques alone or in combination with the official methods to quantify dietary fiber will help researchers gain a better understanding of carbohydrates. The traditional and novel official methods developed to analyze dietary fiber are discussed in detail in this chapter, paying special emphasis to the recent advances in analytical techniques. This includes chromatographic methods (liquid, gas, and thin layer chromatography), nonchromatographic techniques (field flow fractionation and capillary electrophoresis), and other tools to elucidate the chemical structure of carbohydrates, such as nuclear magnetic resonance and Fourier transform infrared spectroscopies.


Xs: 2.029686 Ys: 2.5633073 Publish year: 1992 keyword: complex_carbohydrates_diet source: Global title: Effects of Dietary Fiber and Carbohydrate on Glucose and Lipoprotein Metabolism in Diabetic Patients abstract: Dietary recommendations for the treatment of diabetic patients issued by national and international diabetes associations consistently emphasize the need to increase carbohydrate consumption. However, these recommendations have been questioned on the basis of growing evidence that, in both insulin-dependent and non-insulin-dependent diabetic patients, a high-carbohydrate diet does not offer any advantage in terms of blood glucose and plasma lipid concentrations compared with a high-fat (mainly unsaturated) diet. It has been shown repeatedly that a high-carbohydrate diet increases plasma insulin and triglyceride levels and can deteriorate blood glucose control in the postprandial period. However, much of the controversy between advocates and detractors of dietary carbohydrate can be settled by taking into account dietary fiber. Several studies have shown that the adverse metabolic effects of high-carbohydrate diets are neutralized when fiber and carbohydrate are increased simultaneously in the diet for diabetic patients. In particular, these studies demonstrated that a high-carbohydrate/high-fiber diet significantly improves blood glucose control and reduces plasma cholesterol levels in diabetic patients compared with a low-carbohydrate/low-fiber diet. In addition, a high-carbohydrate/high-fiber diet does not increase plasma insulin and triglyceride concentrations, despite the higher consumption of carbohydrates. Unfortunately, dietary fiber represents a heterogenous category, and there is still much to understand as to which foods should be preferred to maximize the metabolic effects of fiber. There are indications that only water-soluble fiber is active on plasma glucose and lipoprotein metabolism in humans. Therefore, in practice, the consumption of legumes, vegetables, and fruits--rich in water-soluble fiber--should be particularly encouraged. The mechanisms by which dietary fiber exerts its hypoglycemic and hypolipidemic activities are unknown. However, the ability of dietary fiber to retard food digestion and nutrient absorption certainly has an important influence on lipid and carbohydrate metabolism. The beneficial effects of high-fiber foods are also exerted by some foods not particularly rich in fiber. The fiber content and physical form of the food can influence the accessibility of nutrients by digestive enzymes, thus delaying digestion and absorption. The identification of these foods with a low-glycemic response would help enlarge the list of foods particularly suitable for diabetic patients. In conclusion, a diet low in cholesterol and saturated fat should be recommended to all diabetic patients to prevent cardiovascular disease. A balanced increase in consumption of fiber-rich foods and unsaturated fat is the most rational way to replace foods rich in saturated fat and cholesterol in the diabetic diet.


Xs: 2.2416315 Ys: 3.5109963 Publish year: 1993 keyword: complex_carbohydrates_diet source: Global title: Colonic fermentation of complex carbohydrates in patients with familial adenomatous polyposis abstract: Decreased production of butyric acid by colonic carbohydrate fermentation may predispose to colonic carcinogenesis, with the implicit assumption that the decrease in faecal butyrate found predates the development of the tumour. The influence of the genetic predisposition to colonic tumours and the presence of colonic polyps on in vitro fermentation of carbohydrates was examined. Stool samples from 11 normal controls and 20 patients with familial adenomatous polyposis (FAP) were incubated anaerobically with a range of carbohydrates. Fermentation patterns were similar for glucose and raffinose. These sugars produced different short chain fatty acid (SCFA) patterns from the two polysaccharides, starch and arabinogalactan, which differed one from the other. The FAP gene carriers with polyps produced less butyrate than normal controls (p < 0.005) and gene carriers without polyps (p < 0.05). There were corresponding decreases in the molar ratios of butyrate. Gene carriers without polyps produced less absolute amounts of acetate than normal controls (p < 0.05) and slightly less total SCFAs (p < 0.05) but were otherwise not significantly different. The decreased production of butyrate noted by other workers may be secondary to the tumours rather than a contributory cause.


Xs: 1.8609796 Ys: 2.0017672 Publish year: 2002 keyword: complex_carbohydrates_diet source: Global title: Postprandial Thermogenesis Is Increased 100% on a High-Protein, Low-Fat Diet versus a High-Carbohydrate, Low-Fat Diet in Healthy, Young Women abstract: The recent literature suggests that high-protein, low-fat diets promote a greater degree of weight loss compared to high-carbohydrate, low-fat diets, but the mechanism of this enhanced weight loss is unclear. This study compared the acute, energy-cost of meal-induced thermogenesis on a high-protein, low-fat diet versus a high-carbohydrate, low-fat diet.
Ten healthy, normal weight, non-smoking female volunteers aged 19-22 years were recruited from a campus population. Using a randomized, cross-over design, subjects consumed the high-protein and the high-carbohydrate diets for one day each, and testing was separated by a 28- or 56-day interval. Control diets were consumed for two days prior to each test day. On test day, the resting energy expenditure, the non-protein respiratory quotient and body temperature were measured following a 10-hour fast and at 2.5-hour post breakfast, lunch and dinner. Fasting blood samples were collected test day and the next morning, and complete 24-hour urine samples were collected the day of testing.
Postprandial thermogenesis at 2.5 hours post-meal averaged about twofold higher on the high protein diet versus the high carbohydrate diet, and differences were significant after the breakfast and the dinner meals (p < 0.05). Body temperature was slightly higher on the high protein diet (p = 0.08 after the dinner meal). Changes in the respiratory quotient post-meals did not differ by diet, and there was no difference in 24-hour glomerular filtration rates by diet. Nitrogen balance was significantly greater on the high-protein diet compared to the high-carbohydrate diet (7.6 +/- 0.9 and -0.4 +/- 0.5 gN/day, p < 0.05), and at 24-hour post-intervention, fasting plasma urea nitrogen concentrations were raised on the high protein diet versus the high-carbohydrate diet (13.9 +/- 0.9 and 11.2 +/- 1.0 mg/dL respectively, p < 0.05).
These data indicate an added energy-cost associated with high-protein, low-fat diets and may help explain the efficacy of such diets for weight loss.


Xs: 2.0415738 Ys: 2.86227 Publish year: 2007 keyword: complex_carbohydrates_diet source: Global title: A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women abstract: More than one billion human adults worldwide are overweight and, therefore, are at higher risk of developing cardiovascular diseases, diabetes, and a variety of other chronic perturbations. Many believe that use of natural dietary supplements could aid in the struggle against obesity. So-called "starch blockers" are listed among natural weight loss supplements. Theoretically, they may promote weight loss by interfering with the breakdown of complex carbohydrates thereby reducing, or at least slowing, the digestive availability of carbohydrate-derived calories and/or by providing resistant starches to the lower gastrointestinal tract.
The present research study examines a dietary supplement containing 445 mg of Phaseolus vulgaris extract derived from the white kidney bean, previously shown to inhibit the activity of the digestive enzyme alpha amylase, on body composition of overweight human subjects.
A randomized, double-blinded, placebo-controlled study was conducted on 60 pre-selected, slightly overweight volunteers, whose weight had been essentially stable for at least six months. The volunteers were divided into two groups, homogeneous for age, gender, and body weight. The test product containing Phaseolus vulgaris extract and the placebo were taken one tablet per day for 30 consecutive days before a main meal rich in carbohydrates. Each subject's body weight, fat and non-fat mass, skin fold thickness, and waist/hip/thigh circumferences were measured.
After 30 days, subjects receiving Phaseolus vulgaris extract with a carbohydrate-rich, 2000- to 2200-calorie diet had significantly (p<0.001) greater reduction of body weight, BMI, fat mass, adipose tissue thickness, and waist,/hip/ thigh circumferences while maintaining lean body mass compared to subjects receiving placebo.
The results indicate that Phaseolus vulgaris extract produces significant decrements in body weight and suggest decrements in fat mass in the face of maintained lean body mass.


Xs: 2.5658057 Ys: 4.0789475 Publish year: 2014 keyword: complex_carbohydrates_diet source: Global title: Dietary effects on human gut microbiome diversity abstract: The human gut harbours diverse and abundant microbes, forming a complex ecological system that interacts with host and environmental factors. In this article, we summarise recent advances in microbiome studies across both Western and non-Western populations, either in cross-sectional or longitudinal surveys, and over various age groups, revealing a considerable diversity and variability in the human gut microbiome. Of all the exogenous factors affecting gut microbiome, a long-term diet appears to have the largest effect to date. Recent research on the effects of dietary interventions has shown that the gut microbiome can change dramatically with diet; however, the gut microbiome is generally resilient, and short-term dietary intervention is not typically successful in treating obesity and malnutrition. Understanding the dynamics of the gut microbiome under different conditions will help us diagnose and treat many diseases that are now known to be associated with microbial communities.


Xs: 2.3224885 Ys: 3.8293989 Publish year: 2014 keyword: complex_carbohydrates_diet source: Global title: A Perspective on the Complexity of Dietary Fiber Structures and Their Potential Effect on the Gut Microbiota abstract: Even though there are many factors which determine the human colon microbiota composition, diet is an important one because most microorganisms in the colon obtain energy for their growth by degrading complex dietary compounds, particularly dietary fibers. While fiber carbohydrates that escape digestion in the upper gastrointestinal tract are recognized to have a range of structures, the vastness in number of chemical structures from the perspective of the bacteria is not well appreciated. In this article, the concept of "discrete structure" is introduced that is defined as a unique chemical structure, often within a fiber molecule, which aligns with encoded gene clusters in bacterial genomes. The multitude of discrete structures originates from the array of different fiber types coupled with structural variations within types due to genotype and growing environment, anatomical parts of the grain or plant, discrete regions within polymers, and size of oligosaccharides and small polysaccharides. These thousands of discrete structures conceivably could be used to favor bacteria in the competitive colon environment. A global framework needs to be developed to better understand how dietary fibers can be used to obtain predicted changes in microbiota composition for improved health. This will require a multi-disciplinary effort that includes biological scientists, clinicians, and carbohydrate specialists.


Xs: 2.5635726 Ys: 4.041007 Publish year: 2014 keyword: complex_carbohydrates_diet source: Global title: The Impact of Diet and Lifestyle on Gut Microbiota and Human Health abstract: There is growing recognition of the role of diet and other environmental factors in modulating the composition and metabolic activity of the human gut microbiota, which in turn can impact health. This narrative review explores the relevant contemporary scientific literature to provide a general perspective of this broad area. Molecular technologies have greatly advanced our understanding of the complexity and diversity of the gut microbial communities within and between individuals. Diet, particularly macronutrients, has a major role in shaping the composition and activity of these complex populations. Despite the body of knowledge that exists on the effects of carbohydrates there are still many unanswered questions. The impacts of dietary fats and protein on the gut microbiota are less well defined. Both short- and long-term dietary change can influence the microbial profiles, and infant nutrition may have life-long consequences through microbial modulation of the immune system. The impact of environmental factors, including aspects of lifestyle, on the microbiota is particularly poorly understood but some of these factors are described. We also discuss the use and potential benefits of prebiotics and probiotics to modify microbial populations. A description of some areas that should be addressed in future research is also presented.


Xs: 2.4112794 Ys: 3.6594355 Publish year: 2020 keyword: complex_carbohydrates_diet source: Global title: Studies on nutritional intervention of rice starch- oleic acid complex (resistant starch type V) in rats fed by high-fat diet abstract: In this study, rice starch-oleic acid complex with well-controlled digestibility was chosen as a supplementary diet for rats fed with high fat diet. Our results demonstrated that rice starch-oleic acid complex supplementation significantly decreased body weight, improved serum lipid profiles, hepatic metabolism and altered the composition of gut microbiota of rats, which might be related to the higher resistant starch (RS) level. Interestingly, rice starch-oleic acid complex supplementation contributed to the proliferation and growth of butyrate-producing bacteria. The Spearman’s correlation analysis revealed that the genus Turicibacter and Romboutsia genus were positively correlated to HDL-c and SOD level. Meanwhile, based on the metagenomic data, Bifidobacteria genus might be a main primary degrader after rice starch-oleic acid complex intake, which was associated with the changes of key starch-degradation enzymes. Overall, our results provided basic data for the rational design of rice starch-based foods with nutritional functions and physiological benefits.


Xs: 4.480523 Ys: -1.6486531 Publish year: 2023 keyword: complex_carbohydrates_diet source: Global title: Effects of Diet Macronutrient Composition on Weight Loss during Caloric Restriction and Subsequent Weight Regain during Refeeding in Aging Mice abstract: Caloric restriction (CR) induces weight loss, but is associated with rapid weight regain upon return to ad libitum feeding. Our aim was to investigate effects of the macronutrient composition of the diet on weight loss and regain in elderly mice. Males, 18 months old, of the C57BL/6J strain were subjected to 4-week 30% CR followed by 4 weeks of ad libitum refeeding on either high-carb (HC), high-fat (HF) or high-protein (HP) diets (n = 22 each). Mice (n = 11) fed a chow diet ad libitum served as a control group (CON). Body mass and food intake were monitored daily. Twenty-four-hour indirect calorimetry was used to assess energy expenditure and substrate oxidation. Muscle and fat mass were evaluated with dissection of the tissues. Serum leptin and ghrelin levels were also measured. CR-induced weight loss did not differ between the diets. Weight regain was particularly fast for HF as mice overshot their initial weight by 12.8 ± 5.7% after 4-week refeeding when HC and HP mice reached the weight of the CON group. Weight regain strongly correlated with energy intake across the groups. The respiratory exchange ratio was lower in HF mice (0.81 ± 0.03) compared to HC (0.94 ± 0.06, p < 0.001), HP (0.89 ± 0.04, p < 0.001) and CON mice (0.91 ± 0.06, p < 0.01) during the refeeding. Serum leptin levels were higher in HF mice (1.03 ± 0.50 ng/mL) compared to HC (0.46 ± 0.14, p < 0.001), HP (0.63 ± 0.28, p < 0.05) or CON mice (0.41 ± 0.14, p < 0.001). Thus, CR induces similar weight loss in aging mice irrespective of the diet’s macronutrient composition. An HF diet leads to excessive energy intake and pronounced gain in body fat in spite of increased fat oxidation and serum leptin during the refeeding after CR.


Xs: 1.7363188 Ys: 2.2386956 Publish year: 2007 keyword: complex_carbohydrates_diet source: Global title: Low-carbohydrate diets and performance abstract: Athletes are continually searching for means to optimize their performance. Within the past 20 years, athletes and scientists have reported or observed that consuming a carbohydrate-restricted diet may improve performance. The original theories explaining the purported benefits centered on the fact that fat oxidation increases, thereby "sparing" muscle glycogen. More recent concepts that explain the plausibility of the ergogenicity of low-carbohydrate, or high-fat, diets on exercise performance pertain to an effect similar to altitude training. We and others have observed that although fat oxidation may be increased, the ability to maintain high-intensity exercise (above the lactate threshold) seems to be compromised or at least indifferent when compared with consumption of more carbohydrate. That said, clinical studies clearly demonstrate that ad libitum low-carbohydrate diets elicit greater decreases in body weight and fat than energy-equivalent low-fat diets, especially over a short duration. Thus, although low-carbohydrate and high-fat diets appear detrimental or indifferent relative to performance, they may be a faster means to achieve a more competitive body composition.


Xs: 2.1590333 Ys: 2.4989986 Publish year: 2001 keyword: complex_carbohydrates_diet source: Global title: DIETARY MANAGEMENT OF DIABETES MELLITUS abstract: OBJECTIVES: To compare the efficacies of wheat and gram bran diets while seeing their effectson serum glucose and some of the lipids in alloxan-induced diabetic rats. DESIGN:Comparative study. PERIOD: May 1997 to June 1997 (A total of 5 weeks). MATERIAL &METHOD: A total of 8 mixed-sex albino rats were made diabetic by injecting 5 percent alloxan,intra-peritonially. Rats were divided into 2 groups of 4 rats each and fed separately on 5 percent wheat andgram bran diets for one month. RESULTS: Serum glucose decreased by 66.3 percent, triglycerides 38.17percent, serum cholesterol 24.17 percent and faecal cholesterol 75.47 percent in rats fed on gram bransupplemented diet, while rats fed on wheat bran supplemented diet showed serum glucose decreased by 54.5percent, triglycerides 29.2 percent, serum cholesterol 16.26 percent and faecal cholesterol 69.09 percent.CONCLUSION: Results revealed that gram bran showed more serum glucose and lipids lowering actionas compared to wheat bran.


Xs: 4.014512 Ys: 3.8876987 Publish year: 2018 keyword: complex_carbohydrates_diet source: Global title: Nutritional Requirements of the Siberian Sturgeon: An Updated Synthesis abstract: Sturgeon aquaculture grows fast with 465% increasing through 2003–2013. Unfortunately, there is no special culture system or nutritional requirements for these valuable species. Among 27 different sturgeon species, Siberian sturgeon Acipenser baerii is one of the best sturgeon fish for culture in different environments with high growth rate and adaptation to captivity. With growing Siberian sturgeon aquaculture, nutritional requirements at any life stage and culture condition should be considered. This chapter provides basic information and recent data on nutrient requirements of Siberian sturgeon to illuminate the way for sturgeon aquaculturists, feed factories, and researchers to improve and provide appropriate specialized feeds for the fish. Hence, this chapter is focused on macro- and micronutrients, feeding practices, and starvation effect of Siberian sturgeon.


Xs: 3.5913332 Ys: 1.306823 Publish year: 2019 keyword: thai__HDL_in_foods source: Thai title: Associations among serum folate, waist-to-hip ratio, lipid profile, and eating habits with homocysteine in an elderly Thai population abstract: A lower serum folate level is common in older populations and is associated with increased serum homocysteine concentration. In turn, an elevated homocysteine level is associated with increased risk of cardiovascular disease and age-related diseases. Contemporary studies of folate and dietary risk factors for cardiovascular disease among the elderly population in Thailand are lacking. This cross-sectional study aimed to investigate the relationships among serum folate, homocysteine level, and nutritional status in the elderly Thai. Three hundred individuals, aged 60 years and over, underwent anthropometric and physiological measurements, and biochemical parameters, and eating habits were also determined. Folate insufficiency was found in approximately 35% of subjects. Folate and homocysteine showed a significant inverse correlation. Serum homocysteine levels rose with increasing age. Folate deficiency and high waist-to-hip ratio were associated with 7-fold and 2.5-fold increased risk for hyperhomocysteinemia, respectively. There were positive correlations between homocysteine and waist-to-hip ratio and systolic blood pressure, but a negative correlation between homocysteine and high-density lipoprotein (r = -0.239, p < 0.01), which are markers for cardiovascular disease risk. Folate negatively correlated with body mass index, waist-to-hip ratio, and diastolic blood pressure, but positively with high-density lipoprotein (r = 0.162, p < 0.01). Investigation of eating habits showed that low consumption of green leafy vegetables and high consumption of sugary foods were associated with high homocysteine levels. Given associations between nutritional status and cardiovascular disease confirmed in this study, nutrition education, holistic health promotion, and appropriate behavioral modification of eating habits represent important measures for preventing premature cardiovascular disease in the elderly Thai population.


Xs: 3.7689602 Ys: 2.4221077 Publish year: 2015 keyword: thai__HDL_in_foods source: Thai title: Effect of phytosterols and inulin-enriched soymilk on LDL-cholesterol in Thai subjects: A double-blinded randomized controlled trial abstract: Hypercholesterolemia, particularly high LDL-c and non-HDL-c levels, is a traditional risk for cardiovascular disease. Ingestion of diets containing phytosterols and inulin can reduce plasma LDL-c and triglyceride levels, respectively. Phytosterols and inulin-enriched soymilk may be an alternative for a supplemental diet to improve both LDL-c and non-HDL-c to reduce the risk of cardiovascular disease.
Two hundred and forty subjects who were 18 years old or older and had a baseline LDL-c of 130 mg/dl or higher were enrolled into the double-blinded randomized controlled trial study. Subjects were randomly assigned into the study group that received 2 g/day of phytosterols and 10 g/day of inulin-enriched soymilk or into the control group that received standard soymilk. The lipid profile was measured every 2 weeks for 8 weeks. Primary outcomes were 1) to determine the LDL-c reduction after consumption of phytosterols and inulin-enriched soymilk for 8 weeks and 2) to compare the difference of the LDL-c levels between the study and control groups. The secondary outcomes were to compare the difference of TC, TG and HDL-c between the study and control groups.
At the end of the study, the median LDL-c levels decreased significantly from 165 (132, 254) mg/dl to 150 (105, 263) mg/dl in the study group (p < 0.001) and from 165 (130, 243) mg/dl to 159 (89, 277) mg/dl in the control group (p = 0.014). The LDL-c reduction was significantly better in the study group (−10.03 %, (−37.07, 36.00) vs −1.31 % (−53.40, 89.73), p < 0.001). TC also reduced significantly by 6.60 % in the study group while it reduced only by 1.76 % in the control group (p < 0.001). There were no statistical differences in TG and HDL-c levels between both study groups. The adverse events in the study group and the control groups were not different (RR 1.33 [0.871-2.030, 95 % CI]).
Daily consumption of soymilk containing 2 g of phytosterols and 10 g of inulin reduced TC and LDL-c better than standard soymilk. It had no effect on TG and HDL-c levels compared to standard soymilk. Both soymilk products were comparably safe.
Trial registration
Thai Clinical Trial Registry: TCTR20150417001 date: April 17, 2015


Xs: 3.0550985 Ys: 1.2397543 Publish year: 2021 keyword: thai__HDL_in_foods source: Thai title: Dyslipidemia in Apparently Healthy Population of Dera Ismail Khan, Khyber Pakhtunkhwa Province, Pakistan abstract: Dyslipidemia and its high prevalence in patients of hypertension and other non-communicable diseases is increasing. The aim of current study was to highlight the dyslipidemia in apparently healthy population by lipid profiling in Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan. 150 individuals apparently healthy and with no previous records of hyperlipidemia were recruited. Blood plasma samples were collected aseptically from healthy individuals for determination of lipid profile. Blood plasma samples were collected aseptically. Total cholesterol (TC) levels High density lipoprotein cholesterol (HDL-C) levels, Triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) were determined. The 150 healthy subjects were between 20-70 years. Mean plasma levels of TC was 166.4 ±28.45 mg/dl, HDL-C was 48.34 ±8.79 mg/dl, 48.34 ±8.79 mg/dl, LDL-C was 87.42 ±29.82 mg/dl and TG were 151 ±65.92 mg/dl. TC and HDL-C levels were desirable and better. The level of LDL-C level below 100 mg/dl. The triglyceride level was recorded above upper limit. There is a need to investigate the problem of dyslipidemia at the community level. The high TC level in healthy population is an alarming situation and could be used to predict future complications associated with it.


Xs: 4.0116935 Ys: 2.5624566 Publish year: 2015 keyword: thai__HDL_in_foods source: Thai title: Monascus purpureus-fermented Thai glutinous rice reduces blood and hepatic cholesterol and hepatic steatosis concentrations in diet-induced hypercholesterolemic rats abstract: Red yeast rice (RYR) is a fermented product used as a food supplement to promote blood circulation and lower blood cholesterol levels in eastern Asia. Interestingly, monacolin K is the most active compound in RYR that proved to inhibit HMG-CoA reductase in the cholesterol biosynthesis pathway.
The hypocholesterolemic effects of oral administration of Thai RYR, produced by fermentation of Thai glutinous rice (Oryza sativa L. var. Niaw San-pah-tawng) with Monascus purpureus CMU 002U, were determined in normal and hypercholesterolemic rats. The rats were divided into six groups, and fed two different kinds of diet. Groups I-II, normal rats fed with a normal diet (SP-diet), were treated with distilled water (SP-control) and 2.0 g/kg/day of RYR extract (SP-2 g). In Groups III-VI, the rats were rendered hypercholesterolemic by feeding them a high fat and cholesterol diet (HFC-diet), and were treated with distilled water (HFC-control), 1.0 g/kg/day (HFC-1 g), 2.0 g/kg/day (HFC-2 g) of RYR extract, and 5.0 mg/kg/day of rosuvastatin (HFC-rosuvastatin) for 30 days, respectively.
The RYR extract significantly decreased the concentrations of serum total cholesterol and low density lipoprotein cholesterol (LDL-C), atherosclerotic index, LDL-C/HDL-C ratio and hepatic cholesterol levels in both HFC-1 g and HFC-2 g groups (p < 0.05) as compared with the HFC-control group, and with no significant change in high density lipoprotein cholesterol (HDL-C) concentrations among all six groups. The reduction of serum TC and LDL-C also paralleled the observed changes in mRNA expressions of the genes involved in cholesterol biosynthesis and homeostasis in the liver. The hypercholesterolemic rats treated with RYR extract were significantly higher in LDLR and HMGR expression, but lower in CYP7A1 expression when compared to the untreated hypercholesterolemic rats (HFC-control) (p < 0.05). The hepatic injuries in hypercholesterolemic rats were also obviously alleviated by RYR extract.
The extract of Thai RYR possessed potent hypocholesterolemic and anti-atherogenic activities in diet-induced hypercholesterolemic rats. The possible mechanism involving cholesterol-lowering potential of the extract might contribute to its ability to increase LDL-C endocytosis in hepatocyte and to competitively inhibit HMG-CoA reductase, a key enzyme for cholesterol biosynthesis in liver.


Xs: 3.3222392 Ys: 0.50402117 Publish year: 2004 keyword: thai__HDL_in_foods source: Thai title: Eating behaviors of elderly persons with hyperlipidemia in urban Chiang Mai abstract: The objective of the present ethnographic study was to describe the eating behaviors of elderly persons with hyperlipidemia. Twenty-one elderly subjects with hyperlipidemia and their relatives volunteered to be included in the study. Focus group and in-depth interviews with participant observations were used for data collection. Each transcript from interviews and observations were analyzed using content analysis. Subjects were asked to validate findings and ethical considerations were maintained throughout the study. When discussing the meaning of food, three themes emerged: (i) substances make people strong or healthy; (ii) food is like medicine and; (iii) food causes illness. Most subjects had learned about food and nutrition from their parents or relatives and from school. Regarding food procurement, most bought food such as fish or other seafood, meat and eggs from the fresh markets nearby almost daily. All subjects cooked their own traditional northern Thai food, such as Hung-le (northern curry) and preferred seasoning such as fish sauce, pepper and herbs. They ate when they were hungry or after they had finished working. The present study reflected that northern Thai culture strongly influences the participants' eating behaviors.


Xs: 3.0497894 Ys: 0.732366 Publish year: 2022 keyword: thai__HDL_in_foods source: Thai title: Dietary diversity associated with risk of cardiovascular diseases among community-dwelling older people: A national health examination survey from Thailand abstract: Background
Cardiovascular diseases (CVD) are the common comorbidities in older people. Healthy diet is an essential strategy to alleviate the risk of developing CVD. Dietary diversity (DD) is an indicator of diet quality. Currently, limited research exists regarding DD and CVD in older people in developing countries, such as Thailand, despite rapid growth of older population. Therefore, this study aims to determine associations of DD with the risk of CVD and the cardiometabolic risk factors among Thai older people.

Methods
This cross-sectional study used the sub-sample of the fifth Thai National Health Examination Survey conducted from 2013 to 2015. A total of 6,956 older people aged 60 years and older and no pre-existing CVD were included.
Dietary diversity score (DDS) was assessed the consumption of eight food groups using food frequency questionnaires. Each food group was scored from 0 to 4. The DDS was calculated as the sum of the scores (0–32). The risk of CVD was calculated by using a Thai cardiovascular (CV) risk score. The cardiometabolic risk factors included hypertension, diabetes mellitus (DM), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels. Data were adjusted for a complex survey design and analysed using linear and logistic regression models.

Results
In the adjusted model, DDS had a significant negative association with log-Thai CV risk score, with adjusted β (95% CI) values of −0.01 (−0.01, −0.01). Regarding the cardiometabolic risk factors, DDS had a significant negative association with hypertension, DM and log-TG levels, with adjusted OR (95% CI) values of 0.97 (95% CI 0.97, 0.98) for hypertension, 0.94 (0.93, 0.95) for DM, and adjusted β (95% CI) values of −0.002 (−0.004, −0.001) for log-TG level. DDS was positively associated with TC and LDL-C, with adjusted β (95% CI) values of 0.59 (0.38, 0.80) for TC and 0.59 (0.38, 0.79) for LDL-C levels, while DDS was not associated with HDL-C level.

Conclusion
Higher DD was associated with a lower risk of CVD among Thai older people. The nutritional policies or interventions should encourage a diverse food intake for the prevention of CVD in this population.


Xs: 3.1606615 Ys: 0.7488492 Publish year: 2018 keyword: thai__HDL_in_foods source: Thai title: Dietary patterns and their association with the components of metabolic syndrome: A cross-sectional study of adults from northeast Thailand abstract: Background: Nutritional transition influences a shift in eating behaviour that is associated with a rise in the prevalence of non-communicable diseases (NCDs). Metabolic syndrome (MetS) comprises a set of NCD risk factors. This study aimed to investigate dietary patterns and to determine the relationship between dietary patterns and MetS and its components.
Methods: A cross-sectional study was conducted among 468 healthy adults aged 35–60 years who were residents of a semi-urban district of one of the central provinces in the northeast of Thailand. A factor analysis identified dietary patterns based on the consumption of 21 food groups, which were assessed by using a semi-quantitative food frequency questionnaire. MetS was identified by using the harmonized criteria that were stipulated by six leading international organisations. The association between dietary patterns and MetS and its components were evaluated by multiple logistic regressions. The confounding factors adjusted in the model were age, sex, smoking status, physical activity, and medication intake.
Results: Two dietary patterns were identified: a traditional pattern characterised by high intakes of sticky rice and animal source foods; a mixed pattern included high intakes of white rice and a variety of food groups. The two dietary patterns did not show any association with MetS. Participants in the highest tertile of the traditional pattern was significantly related to high triglycerides (adjusted OR = 1.74, 95% CI: 1.10–2.88), in comparison to those from the lowest tertile, whereas participants in the highest tertile of the mixed pattern was inversely associated with abdominal obesity (adjusted OR= 0.49, 95% CI: 0.30–0.81) than those in the lowest tertile.
Conclusions: Adherence to a traditional dietary pattern among the northeast Thai adults, in the context of nutrition transition, was associated with high triglyceride levels while the mixed dietary pattern was inversely related to abdominal obesity.


Xs: 2.9512267 Ys: 1.112865 Publish year: 2007 keyword: thai__HDL_in_foods source: Thai title: Comparative study of LDL cholesterol levels in Thai patients by the direct method and using the Friedewald formula abstract: In this study, low-density lipoprotein cholesterol (LDL-C) levels by direct measurement and estimation using the Friedewald formula, were compared among 1,016 Thai patients. The study assessed blood samples from out-patients sent to the Clinical Chemistry Laboratory, Department of Clinical Pathology, Rajvithi Hospital, Ministry of Public Health, for measurement of total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels, January 2004-December 2005. Patients' ages ranged 8-89 years, 573 (56.4%) were females. Linear regression analysis showed the two methods had highly significant correlation coefficients (p<0.001). Upon comparing the two methods, at TG levels of 151-200 mg/dl, bias was 18.3 mg/dl; and for TG levels of 201-300 mg/dl, bias was lower at 11.4 mg/dl; for TG levels of 301-400 mg/dl, bias increased to 20.9 mg/dl. The direct assay meets currently established analytical performance targets and may be useful for the diagnosis and management of hyperlipidemic patients. The Friedewald formula did not give a homogeneous performance when estimating LDL-C levels in samples with different TG levels.


Xs: 3.4418454 Ys: 1.8175374 Publish year: 2006 keyword: thai__HDL_in_foods source: Thai title: Assessment of hormonal and metabolic effects of dietary fiber in young Thai women abstract: To investigate whether daily dietary fiber intake at the reference level has any impact on studied hormones in a population of Thai women.
Twenty-eight healthy Thai women (aged 18-20 years, BMI 18.5-25 kg/m2) with a history of regular menstrual cycles committed themselves to prepared food without changing the usual ratio of three major macronutrients. Dietary fiber from natural source at the amount of 8-10 g/day equal to their regular consumption was added to their daily diet for one menstrual cycle, then, increased to be 25-30 g/day for another 2 successive cycles. A single blood sample on midluteal day (day 18-23) was obtained in all three cycles. Plasma luteinizing hormone, follicle stimulating hormone, prolactin, estradiol, progesterone, cortisol, and insulin together with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides were analyzed.
The measured hormones and lipids did not change significantly when compared between a control and two experimental cycles (p > 0.05).
Short-term consumption of 25-30 g/day fiber diet as recommended by the Reference Daily Intake (RDI) in a Thai population did not alter the studied hormones and lipids thus did not create any health problems.


Xs: 3.0691445 Ys: 0.7035151 Publish year: 2003 keyword: thai__HDL_in_foods source: Thai title: Cardiovascular risk factor levels in urban and rural Thailand - The International Collaborative Study of Cardiovascular Disease in Asia (InterASIA) abstract: Background Vascular mortality is increasing in economically developing countries but reliable data about the determinants of cardiovascular disease are few. The International Collaborative Study of Cardiovascular Disease in Asia (InterASIA) was designed to obtain,precise estimates of cardiovascular risk factor levels in the adult population of Thailand. Design A complex sample survey. Methods Data from a structured questionnaire, brief physical examination and a blood sample were collected from 5305 individuals aged 35 years or older (response rate 68%). Mean risk factor levels were calculated for eight groups defined by age and sex in 18 representative urban and rural areas of Thailand. Population risk factor levels were calculated by applying sampling weights derived from the 2000 Thai Census and allowing for the complex sampling design. Results The estimated mean (standard error) population blood pressure was 120/76 (0.7/0.5) mmHg, mean serum total cholesterol was 5.2 (0.06) mmol/l, mean body mass index was 24 (0.2) kg /m(2), mean fasting plasma glucose was 5.6 (0.06) mmol/l, the proportion with diabetes 9.6 (1)% and the proportion of current smokers was 25 (3)%. There were estimated to be 5.1 (0.5) million individuals with high blood pressure, 4.4 (0.4) million with high total cholesterol, 8.9 (0.8) million overweight or obese, 2.4 (0.2) million with diabetes and 6.2 (0.9) million current smokers. Mean levels of all major risk factors, except smoking, were worse in urban compared with rural areas. However, except for total cholesterol, the absolute numbers of individuals with abnormal risk factor levels were highest in rural areas. Conclusion Absolute levels of cardiovascular risk factors in Thailand are high. Effective risk factor control strategies that target both rural and urban areas of Thailand have the potential to avert much premature cardiovascular disease. (C) 2003 Lippincott Williams Wilkins.


Xs: 3.1084464 Ys: 0.8555001 Publish year: 2022 keyword: thai__HDL_in_foods source: Thai title: Validation of a Thai semiquantitative food frequency questionnaire (semi-FFQ) for people at risk of metabolic syndrome abstract: Background
Food frequency questionnaires (FFQ) are a useful dietary assessment tool to determine relationships between diet and non-communicable diseases (NCDs). Our purpose was to validate a semiquantitative FFQ (semi-FFQ) for Thais at risk of metabolic syndrome (MS).

Methods
The study identified 345 men and women aged 30 to 65 years were enrolled and invited to participate in data collection for 4 weeks. They were asked to maintain a 4-day food record and partook in a semi-FFQ interview during week 4. Urine samples and biochemical results related to MS were collected. Validation results were associated with 3 primary nutrients for MS (sugar, fat, and sodium) and biochemical results (blood glucose, lipid profiles, blood pressure, and 24-hour urine sodium).

Results
Ninety-four participants were enrolled (54 in a “urine-collection not-required” group and 40 in a “urine collection” group). The level of each key MS nutrient significantly increased commensurate with rises in semi- FFQ estimated intakes. Correlation coefficients (r) were as follows: fasting blood glucose, r = 0.293 (fruits) and r = 0.285 (desserts); triglycerides, r = 0.252 (a la carte-dishes); LDL-cholesterol, r = 0.205 (rice-with-topping dishes); systolic blood pressure, r = 0.272 (snacks) and r = 0.190 (a la carte dishes).

Conclusions
The semi-FFQ helps assess dietary patterns of Thai populations at risk of NCDs.


Xs: 3.40091 Ys: 1.3671297 Publish year: 2010 keyword: thai__HDL_in_foods source: Thai title: Supplement of three eggs a week improves protein malnutrition in Thai children from rural areas abstract: Protein Malnutrition is one of the most important health indexes that affect children's growth and development. In Thailand National Health Survey 2004, 21.5% of primary school students living in the rural area were below the 90th percentile of the standard weight for age.
To compare nutritional status with serum proteins and lipids, and to determine the effect of egg supplement for primary school students aged 6-15 years.
A randomized experimental study was performed in 417 participants received an addition of either three or ten eggs per week for 12 consecutive weeks to basal diet.
The anthropometric and biochemical indexes were measured, 29.1% and 20.8% of whom were Protein Malnutrition according to serum albumin and PreAlbumin's criteria, respectively. Albumin and PreAlbumin levels were positively correlated with Total Cholesterol and LDL-C levels. No difference in any biochemical index has been found between 3 eggs/wk group and 10 eggs/wk group. Besides, due to continuing egg supplement, Total Cholesterol, LDL and ratio of Total Cholesterol to HDL level have decreased (p < 0.001) but albumin, PreAlbumin and HDL levels have demonstrated significantly increasing levels (p < 0.001).
Nowadays in rural areas of Thailand there are still primary school students with protein malnutrition especially in rural area. An addition of at least 3 eggs/wk supplements can effectively correct the problem of protein malnutrition among primary school students at risk as shown by biochemical indices, and it benefits the blood cholesterol level as well.


Xs: 3.2196956 Ys: 0.5296017 Publish year: 2011 keyword: thai__HDL_in_foods source: Thai title: Prevalence of overweight and obesity in Thai population: Results of the National Thai Food Consumption Survey abstract: Overweight and obesity are considered a serious health problem in Thailand. This study examined the prevalence of overweight and obesity in a nationally representative sample of Thai children and adults based on international standards. A cross-sectional population survey of 16,596 Thais aged 3 years and over was conducted. Heights and weights were obtained using standardized methods. Estimates of the overweight and obesity prevalence in children, adolescents, and adults were computed. The prevalence of overweight and obesity among children and adolescents aged 3 to 18 years was 7.6% and 9.0%, respectively, and was higher among boys than girls. Among adults, using the the Regional Office for the Western Pacific (WPRO) standard, 17.1% of adults were classified as overweight [body mass index (BMI) 23.0-24.9 kg/m²], 19.0% as class I obesity (BMI 25.0-29.9 kg/m²), and 4.8% as class II obesity (BMI ≥ 30.0 kg/m²). Using the World Health Organization (WHO) definition, 19.0% were overweight (BMI 25-29.9 kg/m²), 4.0% class I obesity (BMI 30.0-34.9 kg/m²), 0.8% class II obesity (BMI 35.0-39.9 kg/m²), and 0.1% class III obesity (BMI ≥ 40.0 kg/m²). There was a vast difference in obesity prevalence between the WHO and the WPRO criteria. Obesity prevalence when using the WPRO definition (23.8%) was almost five times greater than when defined with the WHO standard (4.9%). The present study found a high prevalence of overweight and obesity in nationally representative sample of the Thai population. Higher rates of overweight and obesity prevalence were computed using the WPRO standard when compared to the WHO standard.


Xs: 3.0303102 Ys: 0.6151041 Publish year: 2008 keyword: thai__HDL_in_foods source: Thai title: Effect of an empowerment-based nutrition promotion program on food consumption and serum lipid levels in hyperlipidemic Thai elderly abstract: This quasi-experimental study examined the effects of an empowerment-based nutrition promotion program on food consumption and serum lipid levels among hyperlipidemic Thai elderly. Fifty-six experimental subjects received the program; 48 control subjects maintained their habitual lifestyle. The statistical methods used were the t-test, Z-test, and chi2/Fisher's exact test. After the program, the consumption of high saturated fat, cholesterol, and simple sugar diets was significantly lower for the experimental group than for the control group. The percentage change of the serum total cholesterol of the experimental subjects was significantly higher than that of the control subjects. The number of experimental subjects that changed from hyperlipidemia to normolipidemia significantly increased compared to that for the control subjects. The implementation of this program was related to an improvement in food consumption and serum lipid levels among hyperlipidemic Thai elderly and, therefore, has implications for practice.


Xs: 2.946683 Ys: 3.984666 Publish year: 2021 keyword: thai__HDL_in_foods source: Thai title: Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial abstract: The cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and
glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy and glucose metabolism, immunomodulation, and brain function. The frequency of overweight is increasing, and the main causes for this are highly processed foods and less active lifestyles. Research is underway to unravel the probable relationship between obesity and intestinal microbiota. Here, we propose a method to understand and elucidate the synergistic function of prebiotics and probiotics in treating obesity. The biomarkers of obesity, such as cholesterol, gut permeability, oxidative stress, bacterial toxins, cytokines, and short-chain fatty acids, were analyzed in
Thai obese individuals after being supplemented with a synbiotic preparation containing Lactobacillus paracasei, Bifidobacterium longum, Bifidobacterium breve, inulin, and fructooligosaccharide. The results reveal that the supplementation of synbiotics significantly altered the obesity-associated biomarkers in an appositive way. Further studies are warranted to use synbiotics as an adjuvant therapy for the management of obesity-related health issues.


Xs: 2.692478 Ys: 0.29967842 Publish year: 2016 keyword: thai__HDL_in_foods source: Thai title: Cost-Effectiveness Analysis of the Self-Management Program for Thai Patients with Metabolic Syndrome abstract: Background:
Lifestyle modification programs are partly evaluated for their usefulness.

Objectives:
This study aimed to assess the cost-effectiveness and healthy lifestyle persistence of a self-management program (SMP) for patients with metabolic syndrome (MetS) in Thai health care settings.

Methods:
A cost-effectiveness analysis was performed on the basis of an intervention study of 90 patients with MetS randomly allocated to the SMP and control groups. A Markov model with the Difference-in-Difference method was used to predict the lifetime costs from a societal perspective and quality-adjusted life-years (QALYs), of which 95% confidence intervals (CIs) were estimated by bootstrapping. The cost-effectiveness analysis, along with healthy lifestyle persistence, was performed using the discount rate of 3% per annum. Parameter uncertainties were identified using one-way and probabilistic sensitivity analyses.

Results:
The lifetime costs tended to decrease in both groups. The SMP could save lifetime costs (-2310 baht; 95% CI -5960 to 1400) and gain QALYs (0.0098; 95% CI -0.0003 to 0.0190), compared with ordinary care. The probability of cost-effectiveness was 99.4% from the Monte-Carlo simulation, and the program was deemed cost-effective at dropout rates below 69% per year as determined by the threshold of 160,000 baht per QALY gained. The cost of macrovascular complications was the most influencing variable for the overall incremental cost-effectiveness ratio.

Conclusions:
The SMP provided by the health care settings is marginally cost-effective, and the persistence results support the implementation of the program to minimize the complications and economic burden of patients with MetS.


Xs: 4.10543 Ys: 1.1286367 Publish year: 2020 keyword: thai__HDL_in_foods source: Thai title: Longitudinal Study of Metabolic Biomarkers among Conventional and Organic Farmers in Thailand abstract: The aim of this longitudinal study is to assess how pesticide use may impact metabolic biomarkers by collecting and comparing data from conventional (n = 13) and organic farmers (n = 225) every eight months for four rounds. Farmers were interviewed about family health history, food consumption behaviors, self-reported health problems, agricultural activities, and history of pesticide use. Systolic and diastolic blood pressure and body mass index (BMI) were measured. Blood samples were collected for total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), blood glucose, and triglycerides. A linear mixed model with random intercepts for subjects was used to compare the metabolic biomarkers between conventional and organic farmers and to examine the impact of the number of pesticide spray days for all four rounds after controlling for covariates. The conventional farmers reported using insecticides, herbicides, and fungicides. The marginal means for chemical farmers were significantly higher than organic farmers for total cholesterol, LDL, HDL, glucose, systolic and diastolic blood pressure, BMI, and waist circumference. Increasing the number of days of spraying either insecticides or fungicides was associated with an increase in HDL, LDL, and cholesterol levels. Increasing the number of herbicide spray days was associated with an increase in systolic and diastolic blood pressure and a decrease in BMI. These findings suggest that pesticide-using conventional farmers may be at higher risk of metabolic disease in the future.


Xs: 3.1418114 Ys: 0.5960386 Publish year: 2021 keyword: thai__HDL_in_foods source: Thai title: Metabolic syndrome in Thai adolescents and associated factors: the Thai National Health Examination Survey V (NHES V) abstract: Background
Presence of metabolic syndrome (MetS) in early life may influence cardiovascular outcome later in adulthood. There is limited data regarding MetS among Thai adolescents. This study aimed to estimate the prevalence of MetS and related factors in Thai adolescents.

Methods
Data on MetS components of 1934 Thai adolescents aged 10–16 years were obtained from the 5th National Health Examination Survey. Age at first screen time exposure, duration of screen time, frequency of food intake and physical activities were collected from interviews. MetS was defined according to 3 definitions: International Diabetes Federation (IDF), Cook’s, and de Ferranti’s.

Results
The prevalence of MetS was 4.1% by IDF, 8.0% by Cook’s, and 16.8% by de Ferranti’s definition. The overall prevalence was higher in male (19.0%) than female adolescents (15.3%). The most common MetS components composition among Thai adolescents was high waist circumference with high serum triglyceride and low HDL-cholesterol (40.0% for IDF, 22.6% for Cook’s and 43.5% for de Ferranti’s definition). Exposure to screen media during the first 2 years of life had a 1.3- fold increased odds of MetS by 1 out of 3 definitions (OR 1.30, 95% CI. 1.01–1.68). Duration of physical activity associated with decreased odds of MetS by Cook’s definition (OR 0.96, 95% CI. 0.92–0.99).

Conclusions
The prevalence of MetS among Thai adolescents was higher than previously reported by other studies. Screen media exposure during the first 2 years of life should be discouraged and measures to promote physical activity among children and adolescents should be strengthen.